This chapter examines the socio-cultural dimensions of disability in Low- and Middle-Income Countries (LMICs), focusing on cultural beliefs, social norms, religious practices, and the pervasive stigma surrounding disability. It explores how these factors shape the experiences and inclusion of individuals with disabilities in LMICs, often exacerbating social exclusion and marginalization. This chapter highlights the role of cultural narratives and religious interpretations in shaping societal attitudes and policies, the impact of stigma and discrimination, and the challenges faced by individuals with disabilities and their families. It also explores how these socio-cultural perceptions intersect with other social categories such as gender, age, and socioeconomic status, deepening the marginalization of some groups. Drawing on recent studies, this chapter presents strategies for addressing these challenges, including community engagement, policy interventions, and leveraging religious and cultural leadership. It concludes with a call for global cooperation and the exchange of best practices to foster inclusive societies that respect the dignity and rights of people with disabilities.