Background: The word “migraine” is derived from the Latin word “hemicrania” meaning half skull. The term “migraine” was first used by the Greek physician Galena of Pergamon. Migraine attacks are sensory (nerve, gastrointestinal, and autonomic) symptoms that may occur before or during a migraine attack. Being a common neurological disorder, it affects an estimated 14% population worldwide. According to the Global Burden of Disease Analysis, Migraine is considered as one of the most disabling diseases, and it affects both personal and professional qualities of life. This study is an attempt to investigate the gender based variation in prevalence and pattern of migraine. Materials and methods: A survey was conducted on 50 medically diagnosed migraineurs who consented to participate in the study. Migraine Disability Assessment (MIDAS) Questionnaire was used to study the different aspects of migraine in this population like, number of migraine episodes in a month, duration of each episode, type of medications taken, etc., along with the demographic details. Results: The study group consisted of 50 subjects, out of which 38 were females and 12 were males. 22 subjects aged between the 15–20 years, 19 subjects between 21 and 25 years and 9 subjects greater than 25 years. The mean number of days of migraine headache experienced per month by females was reported to be greater than by males. The mean duration of migraine headache after taking migraine medication was 5.83 ± 3.81 h in females and in males 2 ± 2.09 h per day. Conclusion: The prevalence of migraine in women is higher than in men; females have more severe disease, resulting in a much higher migraine disease burden than indicated by prevalence alone.