Fracturing production is one of the indispensable measures for increasing production in the efficient development of low-permeability reservoirs in the Yanchang Formation of Jing’an Oilfield. But with the improvement of development level and the extension of mining time, particle migration, blockage, condensation of heavy components, decrease in fracture conductivity, and imbalance in injection production relationship will all lead to rapid decline in single well production, making it increasingly difficult to stabilize production. On the basis of analyzing the development characteristics of low-permeability reservoirs in the middle and later stages and the reasons for production decline, based on the understanding of the development status of low-permeability reservoirs in the Yanchang Formation of Jing’an Oilfield, field experiments were carried out on repeated modifications such as fracture turning fracturing technology, oil well water plugging technology, and acidic fracturing fluid technology, and good production increase effects were achieved in field applications. The systematic summary of the application of comprehensive tapping technology for old wells in low permeability reservoirs in the Yanchang Formation of Jing’an Oilfield has important reference significance for improving the single well production of similar reservoirs and repeatedly transforming old wells into power.