In the oil and gas wells with high-temperature and acidic gas environments, it prone to corrode oil well cement, causing deterioration performance and damaging the cement sheath. At the same time, the active bottomhole gas has higher requirement for the anti gas channeling. In order to develop a the oil well cement slurry resistant to corrosion and gas channeling for high-temperature oil and gas well, the key materials of cement slurry were studied, and a high-temperature oil well cement slurry resistant to corrosion and gas channeling was designed. The performances of the cement slurry were studied. The experimental results show that the designed high-temperature anti-corrosion agent and anti gas channeling agent can effectively improve the ability to resist corrosion and gas channeling at high temperatures, significantly reduce the corrosion depth, and shorten the development time of static gel strength. Multi-scale silicon powder as a high-temperature stabilizer can improve the mechanical performance stability of cement paste at high temperatures. The high-temperature anti-corrosion and anti channeling cement slurry system the additive materials studied has good rheological properties, high stability, no free liquid, less 50 mL water loss, adjustable thickening time, and meets the requirements of cementing operations. At the temperature of 180 ℃, the mechanical properties are stable and with strong anti-corrosion ability. The corrosion depth is less than 2 mm, and the development time of static gel strength is within 20 min. The microstructure analysis results indicate that the micro morphology of cement paste is dense and maintains good integrity even after corrosion. This research achievement can provide technical support for preventing gas channeling and cementing operations in deep oil and gas wells with acidic gas.