High-rise building construction is on the rise for several reasons, such as growth in population, migration of people from small towns to cities, the economic rise of nations, and advancements in construction technologies that facilitate the growth of high-rise construction. However, an increase in building heights is accompanied by an increment in wind loading and vibrations caused due to wind-related phenomena. Hence, over a period, high-rise construction has seen growth in unconventional-shaped buildings, which is a passive strategy to mitigate the oscillations induced by the wind. Aim of this paper is the analysis of the variation of mean pressure coefficients on the surfaces of cross-section-modified buildings by providing floor recession at successive height intervals, also known as setbacks, and compare the mean pressure coefficients of setback buildings to the basic square building. For this study, three models of the same height and base area have been taken; a basic square building (SQ), a double-sided setback building (DSB), and a double-sided double setback building (DSDSB). The double-sided setback (DSB) has been provided with setbacks of 10% of base dimension on two opposite sides at mid height, whereas the double-sided double setback (DSDSB) has been provided with setbacks of 10% of base dimension at two opposite sides at 3H/8 and 5H/8 level. Mean pressure coefficients on vertical center lines drawn on all four faces of the buildings have been compared. It was observed that double sided double setback (DSDSB) building exhibited a maximum percentage reduction in suction of around 36% at the rooftop height of 400 mm over the basic square building at 90° wind incidence angle (WIA) for both side faces, which probably indicates that the turbulence generated by the upper setback of DSDSB building was responsible for this reduction.