Thrombophilia’s are the conditions where the inhibitory proteins are deficient, which causes hypercoagulability, and thus venous thrombosis and embolism. Thrombophilias may be inherited (genetic) or acquired. Venous thromboembolism (VTE) [1, 2]. Arterial thrombosis is usually rare. The risk of pregnancy-associated VTE is up to six times that of the general population, with an absolute risk up to 12.2 per 10,000, compared with 2 per 10,000 in nonpregnant women [3]. While this disease is more common in Western countries where pulmonary thromboembolism accounts to 1–5% cause of maternal mortality, this entity is underreported in Indian population. However, one of the Indian studies has reported the incidence of venous thromboembolism disorders in India is as common as in the West. The reported incidence is 17.46/10,000 admissions, and it has been on rise, attributed to an increase in the clinical suspicion among treating physicians [4].