Neuroblastoma (NBL) is the most common malignancy in infants and the most common extracranial solid tumor in children [1]. The outcome is very good in low and intermediate risk disease. However, in high-risk disease, cure rates are below 50% despite aggressive treatment. Neuroblastoma is said to arise from primitive adrenergic neuroblasts of the neural crest cells primarily in the sympathetic ganglion. On light microscopy, it is classically described as a small round blue cell tumor with Homer Wright pseudo rosettes, necrosis, calcification, hyperchromatic nuclei, and scant cytoplasm.