This paper describes fundamental investigation for developing a regenerative cell-culture system composed of acceleration of cell-culture and disintegration of micro capsule including bubbles and cells by shock wave. However, it is difficult to control shock waves for local cell-stimulation in micro scale. In our previous works, to control the working area of shock waves in micro scale, the generation of micro shock wave by using femtosecond laser was tried and measured, and it was found that maximum pressure of the micro shock wave is about 0.4 MPa and the generated micro bubbles are also observed at the laser focal area. However, the mechanisms of generation have not been elucidated yet. In this investigation, femto-second laser induced micro shock wave propagation and bubble behavior is observed and measured by optical system such as photodiode and highspeed camera. It was found that there is a possibility to be generated at 200 ns after laser irradiation after a comparison of the measured value by the photodiode and the measured pressure history. In addition, numerical simulation is conducted by using Euler eq. and Rayleigh-Plesset eq. It was suggested that the duration of the shock wave may be extended when the internal pressure of the generated bubble increases, or an equation such as energy equation may be added.