This paper reports experimental results of shock wave interaction phenomena with multi-layered wire gauze for understanding shock wave pressure attenuation by interaction with various media, related to shock wave medical and biomedical applications. Shock wave interaction experiments were conducted using multi-layered wire gauze with and without water droplet addition to verify the effect of water droplet addition on multi-layered wire gauze. Multi-layered wire gauze composed of four sheets of stainless-steel wire gauze was interacted with micro-explosive-induced spherical shock wave. The process of interaction between the induced shock wave and multi-layered wire gauze was visualized by shadowgraph method and recorded with a high-speed camera. The pressure histories of propagated shock wave pressure after interacting with multi-layered wire gauze were measured simultaneously by using a pressure sensor. High-speed optical visualization of the shock wave interaction behavior with the multi-layered wire gauze and the time history of the pressure after the interaction showed that the arrival time of the primary shock wave was delayed, and the peak overpressure was reduced. Furthermore, the primary shock wave was successfully attenuated by stacking the wire mesh at intervals and adding water droplets.