The focus of this paper is the exploration through the lens of a metabolic urbanism of the complex reciprocities between processes of territorial transformation and “techno-dynamics” which affect/ are affected by the global strategies of economic and political power. These transformations renew the scale and vocabulary of architecture, involving integrated and simultaneously diverse built, cultural, social and natural environments, part of the post-industrial era. These environments, considered within the continuous development of advanced technologies that move permeably across real and virtual, require new coordinated holistic strategies in approaching urbanized metropolitan areas as part of a complex metabolic system, exploring and decoding processes of action/ reaction within the space of flows. In these several operational fields are involved, differently affecting the life of each individual and promoting a detachment/delocalization between place and action, space and feeling of it. Encompassing multiple dimensional scales, and including infrastructure, urbanism, natural resources, production and consumption, technologies define renewed proactive and challenging relationships capable to guarantee recognition and a sense of belonging, spatializing and visualizing our complex and often ephemeral “data-scapes.” New methodologies and tools for performative and networked operational procedures need to be experimented and coordinated through a critical approach merging technologies capable of landing in strategically located and adaptive designs proposals which can promote and support more sustainable and integrated processes of territorial transformation, especially when acting in highly vulnerable localities which challenge entire regions. New urban morphologies and building trans-typologies affecting quality of spaces and life, are then creatively integrated as “techno-scapes” defining our complex “territorial metabolism.”