During substation equipment maintenance, safety in the maintenance area primarily relies on organizational and technical measures. However, practical experience shows that these measures cannot completely prevent misoperations during the maintenance process. To avoid accidental energization incidents at maintenance sites and enhance the safety and efficiency of substation maintenance operations, this paper integrates existing substation monitoring system technologies to implement partitioned management of operational equipment. It investigates key technologies such as intelligent topology recognition, maintenance isolation task setting, data filtering, and equipment status comparison, in order to achieve full-process control of equipment maintenance isolation.