This study investigates the factors influencing the development and implementation of social entrepreneurship education in Vietnamese universities, focusing on managing uncertainties in decision making and institutional strategies. Using a hybrid approach, the research integrates qualitative and quantitative methodologies to develop knowledge models, formulate hypotheses, and assess key determinants. The Partial Least Squares Structural Equation Modeling (PLS-SEM) framework is applied for data analysis and hypothesis testing. The findings reveal that cultural and ethical considerations, collaboration and networking, and institutional support significantly impact the effectiveness of social entrepreneurship education. This study highlights the role of uncertainty, such as variations in institutional priorities and stakeholder expectations, in shaping educational strategies. By addressing these uncertainties, the research contributes to a decision-support framework for integrating sustainable development goals into higher education curricula. These insights provide a pathway for Vietnamese universities and similar contexts to navigate the complexities of fostering social entrepreneurship education.