Scholarlink

In cases of sudden death, where autopsies are blank, coroners face a great challenge in trying to elucidate the cause of death. In the last 20 years, the development of molecular techniques, especially next-generation sequencing (NGS), has allowed the analysis of sets of genes that cause different diseases, which are not observable during necropsy. However, with this methodology challenges may arise, a large amount of information is obtained, which makes its interpretation difficult, especially when, in some cases, antemortem clinical information or family members are not available to complement the genetic analyses, making the forensic context difficult. Additionally, the genetic heterogeneity and pleiotropism presented by different diseases must be considered.

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Complexity of Molecular Analysis by New Generation Sequencing in the Study of Sudden Cardiac Death Within the Forensic Context

  • 章节

  • 发表日期：

    2025年

查看全文
  • Joseph Alape-Ariza,
  • Clara Isabel Bermudez-Santana

摘要

In cases of sudden death, where autopsies are blank, coroners face a great challenge in trying to elucidate the cause of death. In the last 20 years, the development of molecular techniques, especially next-generation sequencing (NGS), has allowed the analysis of sets of genes that cause different diseases, which are not observable during necropsy. However, with this methodology challenges may arise, a large amount of information is obtained, which makes its interpretation difficult, especially when, in some cases, antemortem clinical information or family members are not available to complement the genetic analyses, making the forensic context difficult. Additionally, the genetic heterogeneity and pleiotropism presented by different diseases must be considered.