Floating bridges offer alternative design solutions for sea-crossing where conventional bridges with piers and abutments are not feasible. However, their complex hydrodynamic interactions necessitate detailed modeling and analysis to ensure structural safety, durability, and serviceability. Utilizing OrcaFlex software, this study introduces an advanced computational framework to examine the structural behavior of these bridges under various ocean environmental loading conditions. Based on previous work that highlights the importance of considering inhomogeneous waves, we successfully created a realistic model of a straight pontoon bridge and integrated inhomogeneous wave conditions into the OrcaFlex model. The study mainly focused on the examination of the effects of different mooring configurations on the structural behaviors under extreme conditions. We found that optimized mooring configurations can substantially improve the bridge's resilience to hydrodynamic forces. This research is anticipated to contribute valuable insights into the basic and detailed design of floating pontoon bridges, thereby improving safety and efficiency.