Plant diseases put global food security at risk, resulting in huge crop losses and damage global economy. Even though traditional chemical pesticides are reliable, they are now often linked to harm to the environment, threats to human health, and the rise of pest resistance. Recently, nanomaterials have been used to control plant pathogens by many researchers. Due to the unique antimicrobial impact nanomaterials pose along with no resistance patterns in phytopathogens against nanomaterials, the concept of nano-pesticides comprising of nanomaterials as antimicrobials and delivery agents is rapidly gaining attention. It is because of their unusual physicochemical features, for example, high surface area and easy surface chemistry modification, that nanomaterials prove to be very effective in fighting infections. They allow better precision in spraying and controlled timing of the application and have lower risk to the environment than traditional agrochemicals. In this chapter, different ways nanoparticles stop infections, such as oxidative damage, damaging membranes, and interfering with genes are presented. In addition, the chapter investigates the use of biogenic synthesis, real-world examples, rules governing their use, and related difficulties with scaling up and protecting the environment from nanomaterial toxicity. Applying nanotechnology to integrated pest management can make nano-pesticides a useful choice for managing pest problems without compromising the sustainability rules.