In today’s rapidly evolving global marketplace, efficient and supply chain management is imperative for the success of e-commerce giants like Amazon. This study highlights Amazon’s adoption of Artificial Intelligence (AI) technologies to optimize its supply chain operations. Leveraging AI’s capacity for predictive analytics, automation, and data-driven decision-making, Amazon has revolutionized supply chain processes, from demand forecasting and inventory management to logistics and last-mile delivery. This paper provides an in-depth exploration of the AI-driven initiatives employed by Amazon, showcasing their profound impact on supply chain efficiency and customer satisfaction. Through AI, Amazon has achieved remarkable advancements in demand prediction accuracy, enabling precise inventory allocation, and reducing carrying costs. Furthermore, machine learning algorithms have transformed order fulfillment, enabling faster and more reliable deliveries while minimizing operational costs. The study also highlights Amazon’s utilization of AI-powered robotics and automation within its fulfillment centers, enhancing picking, and packing processes.