In a webinar series hosted by the International Ergonomics Association, the Future of Work Task Force has been eliciting views about the future of work from different regions around the world. Through these insights, we have developed an understanding of the unique challenges that emerge from an intersection of geography and politics. The combination of geographical placement, the strength of political systems to support labor policies, and the financial stability of the economy produce a set of circumstances from which dominant future work practices are likely to emerge. This means that in addressing the future challenges arising from new work systems, human factors and ergonomics will not only have to deal with cross-cultural differences of human interactions with work technology, but also the broader systemic issues arising from politics, religion, and the economy as first outlined by Moray (2000). In this paper I give examples emerging from the different webinars to illustrate how the challenges from the future of work are both predictable and difficult to address.