This chapter delves into the ethical and social dimensions of deploying blockchain in healthcare. It begins with an introduction to core ethical principles—such as autonomy, transparency, and privacy—and examines how these relate to blockchain’s unique capabilities. The chapter explores existing ethical frameworks, like the Belmont Report and bioethics principles, and provides actionable guidelines for ethically implementing blockchain in healthcare. A case study further highlights real-world ethical challenges and potential solutions. The chapter concludes by outlining future ethical considerations and policy recommendations, emphasizing a balanced approach to maximize societal benefits while addressing ethical concerns.