This chapter discusses the intersection of traditional project management and blockchain technology for global healthcare applications. It covers how blockchain adoption follows specific models, such as the Innovation Diffusion Model and Blockchain Readiness Framework. The chapter then explores how traditional methodologies, like the Waterfall and Agile models, can be adapted to the dynamic and regulatory-intensive environment of healthcare. Lastly, it introduces best practices for managing large-scale healthcare applications with a focus on security, scalability, and stakeholder collaboration.