The Bidens species, sometimes called bur marigolds or beggarticks, gained significant interest owing to their diverse pharmacological and biomedical applications in traditional medicine and nutraceuticals around the globe. The scientific research on the phytochemistry and therapeutic applications of Bidens species is systematically examined in this chapter, accenting the species’ geographic range and therapeutic potentials. As determined by phytochemical investigation, numerous Bidens plants contain bioactive substances, including phenolic acids, terpenoids, polyacetylenes, and flavonoids. The pharmacological activity of these phytoconstituents is diverse and includes hepatoprotective, anticancer, anti-inflammatory, antibacterial, and antioxidant properties. For several generations, people from many cultures have used the species of Bidens in traditional medicine. Infections, gastrointestinal issues, and inflammatory problems are just a few of the disorders for which Bidens pilosa has been used throughout Asia. Skin diseases, fever, and malaria have all been treated using Bidens species in African traditional medicine. Bidens plants have also been used for their analgesic, wound-healing, and anti-inflammatory qualities. Furthermore, a growing body of research validates the potential of Bidens species in functional foods and nutraceutical formulations. In preclinical research, extracts and isolated chemicals from Bidens plants have shown promise in treating chronic illnesses like diabetes, cancer, and cardiovascular conditions. Even yet, more investigation is necessary to clarify the molecular mechanisms of action, improve extraction methods, standardize formulations, and assess the safety profiles of products based on Bidens. To sum up, Bidens species are an important source of bioactive substances with a variety of pharmacological characteristics and medical uses. The production of nutraceuticals and pharmaceutical products derived from Bidens can be enhanced through the integration of traditional knowledge with modern scientific approaches for the betterment of world health and well-being.