Genus Bidens is an important genus of the Asteraceae family and is widely distributed in tropical and subtropical regions. The members of this genus have been used in traditional systems of medicine, i.e., Ayurveda, African, and Chinese medicine. Their plants are known to heal wounds, cure snake bites, treat the common cold, fever, etc. Upon evaluation, their extracts have demonstrated anti-hyperglycemic effects, potentially aiding in managing diabetes. They also possess antihypertensive activity, antimalarial activity, immunomodulatory activity, uterotonic effects, wound healing activity, and antiulcer activity. The future of the Bidens species lies in rigorous scientific exploration, collaboration, and responsible utilization. Its diverse bioactivities offer exciting possibilities for healthcare and well-being. However, further research is essential to fully understand its mechanisms and therapeutic potential.