Heavy metals are one of the major environmental pollutants introduced into various ecosystems by rapid industrial development globally. Heavy metals have detrimental impacts on human health and are the root cause of many major illnesses. The zinc content in the soil is affected by the complex process of global warming. Plants absorb zinc either as a bivalent cation or by building a complex with organic ligands in the xylem of their roots, which is then transferred to the plants’ shoots. Zinc is a necessary component that triggers the activation of several enzymes necessary for protein synthesis, growth, and the creation of hormones that promote development in plants, animal, and humans. Nevertheless, increased zinc accumulation is harmful since it causes growth retardation, decreased biomass output, and delays in several metabolic processes, including photosynthesis, transpiration, and nitrogen metabolism. In fact, plants may even die because of elevated Zn concentrations. Certain plant species have the capacity to accumulate elevated levels of zinc in their tissues without displaying any harmful effects. These species that are resistant of zinc can be used in phytoremediation. This chapter focuses on advancements in the understanding of micronutrient absorption and translocation and distribution in plants. The current study also aims to assess zinc availability in the environment, plant uptake and molecular mechanisms of translocation, impact on physiological and biochemical status, hyperaccumulation of zinc, and strategies for enhancing Zn uptake in plants.