The sophistication and frequency of fileless malware attacks present a serious obstacle to current cybersecurity solutions. Existing methodologies can easily be broken with the use of advanced computing techniques. This paper introduces a comprehensive strategy aimed at bolstering cybersecurity defenses against malware threats. By using cutting-edge technologies and methodologies, this paper aims to establish a resilient defense mechanism capable of mitigating the growing complexity and dynamism of malware attacks. The proposed framework is divided into prevention, detection, and monitoring, each leveraging quantum computing and machine learning principles. Each phase results in contributing to an improved system for combating malware. The framework components are assessed for their effectiveness using various tests and evaluation metrics. Each segment proves itself as a potent solution providing a comprehensive approach to detect, prevent, and monitor malware.