Silk fleece inspection task (i.e., removing fine foreign materials from silk fleece) in silk production industries is one such task where workers are required to stand for prolonged hours in a non-neutral posture while using the traditional inspection table. This condition may lead to work-related musculoskeletal disorders (WMSDs) among workers. However, hardly any study examined WMSD risk among silk fleece inspection workers. In this context, a preliminary study has been carried out on the silk industry of Assam in northeast India. The focus of this study was to improve the body postures of workers engaged in silk fleece inspection tasks and minimize the risk of WMSDs among workers in this profession. Ergonomics problems related to the current silk fleece inspection task have been identified through direct observations and interviews with workers. Thus, an ergonomic workstation was designed using CATIA software and tested using the digital human modeling approach. The Rapid Upper Limb Assessment (RULA) method was used to assess modified conditions. This simulation-based evaluation has provided promising results in improving the working posture.