Autism spectrum disorders (ASD) are a group of complex and heterogeneous neurodevelopmental disorders with difficulties in social communication and interaction. The two main areas of challenge for people with autism spectrum disorder are social communication and interaction as well as persistent patterns of restricted and repetitive behavior, interests, or activities and most importantly difficulty in nonverbal communication. The prevalence in increasing without any known etiology; approximately 1 in 54 children are diagnosed with the condition within the United States. Early treatment helps in the improvement of intellectual, language and social activities/interactions. Play therapy is an approach that utilizes playing as the key channel for communication and expression in a structured or unstructured setting. This approach is stranded in the understanding that play serves as the inherent language of children, through which they articulate their thoughts, emotions, and experiences. The play therapy is with controlled and free play activities can help ASD children practice and develop essential skills such as turn-taking, joint attention, and social reciprocity in a supportive and engaging environment. Play therapy is an opportunity for children who are diagnosed with ASD to explore and increase their interests and behaviors while utilizing a flexible and adaptive approach. By introducing new play materials and situations, therapists enable children's interests and foster more adaptable cognitive and behavioral adjustments in them. Playing with children can help them realize and express a mixture of emotions in a risk-free, non-threatening environment while gradually increasing emotional awareness and regulation skills. The play therapy also increases the cognitive, attention, and language development of children with ASD. This chapter explores the relationship between play therapy and ASD. It gives a promising background to include play therapy as a choice of treatment in patients with ASD in different age groups.