Drawing from the Conservation of Resources (COR) theory, this study investigates the link between talent management (TM) practices and intention to leave (ITL) among 519 academics in 20 Chinese universities, focusing on the mediating role of quality of work-life (QWL). Employing partial least squares structural equation modelling (PLS-SEM), the results indicate no direct relationship between TM practices and ITL. However, QWL acts as a mediator, emphasizing its critical role. These findings underscore the need for organizations to prioritize both TM practices and QWL to mitigate ITL. The novelty of this study lies in its comprehensive examination of the indirect effects of TM practices on ITL through QWL, providing new insights into the dynamics of academic retention. According to COR theory, job-related resources from TM and personal resources from QWL impact academics’ ITL. To retain and optimize talented academics, employers must prioritize a high QWL through effective TM practices, ensuring a supportive work environment.