In this modern age of digitalization, the continuous shift of OEMs toward Industry 4.0 has resulted in the need for emerging digital technologies. The metaverse fills this gap and helps transform the traditional business landscape. This research aims to give a clear overview of the metaverse and various technologies constituting the metaverse platform. It also highlights the challenges and opportunities of integrating metaverse technologies into supply chain practices for various supply chain stakeholders. This paper next deep dives into various intricate challenges and categorizes the challenges to offer a clear and structured perspective on the intricate dynamics of metaverse adoption in SCM. Further, the research uses the DEMATEL technique to determine the priority and interrelationship among the identified challenges of integrating metaverse technologies into supply chain practices. The findings of the paper depict that adoption and user-related challenge is the key obstacle in inculcating metaverse into supply chain practices. Similarly, data management and security challenges also pose a major concern regarding the successful adoption of metaverse technologies. This research will help supply chain stakeholders make informed decisions about integrating metaverse technologies and promoting resilience and sustainability in their operations. It also provides insight into different challenges that need to be overcome to have a successful metaverse adoption.