With the continuous operation of distributed power generation into the power grid, more and more attention has been paid to the simulation research to ensure the safe and stable operation of the power system. In order to solve the problems of low stability, low accuracy and Central Processing Unit (CPU) overload in the real-time performance of a single real-time simulation platform applied to multi-energy power systems, a joint real-time simulation method of multi-energy power systems based on heterogeneous platform was proposed. At the same time, a communication interface algorithm was designed to solve the problem of communication differences between different simulation platforms. Furthermore, the controlled source is used as the controlled object of the communication interface at the interface algorithm of the model, and then the topology simulation model of the multi-energy power system is built in Simulink by taking the actual multi-energy power system as an example, and the main network area is simulated by MATLAB in real time and the distribution network part is simulated by CloudPSS according to the division of computing efficiency of the heterogeneous platform. The final simulation results show that the results of the single platform simulation are essentially consistent with those of heterogeneous joint simulation, and the efficiency of the heterogeneous joint real-time simulation is higher than that of the single real-time simulation platform, and the stability of the real-time simulation is better than that of the single real-time simulation platform.