Cancer is a fatal disease of the twenty-first century and a global risk to human well-being representing the second chief cause of death after cardiovascular disease, but some most prevalent and fatal cancers are: breast cancer, lung cancer, liver cancer, prostate cancer, cervical cancer, colorectal cancer, and ovarian cancer among all the others. Chemotherapy is the standard treatment but responsible for systemic toxicity and associated with low therapeutic efficacy due to its difficulty in reaching tumor tissues, high doses, availability of non-selective therapeutic choices, and side effects including nausea, vomiting, anorexia, alopecia, and neuropathy, which further raise the cost of treatment. So, using combination medications would be the most effective and best method to combat these side effects and drug resistance, which either combines the conventional anticancer drug with bioactive natural compounds or two or more bioactive phytoconstituents together. The numerous phytochemicals like phenolics, terpenoids, alkaloids, and organosulfur compounds are dominant in preclinical and clinical research as anti-cancer drugs, so in this instance, nanotechnology has led to maximizing their potential as anti-cancer drugs by enhancing their solubility, stability, and reducing their dose, side effects, and toxicity.