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Nanomaterials are increasingly recognized as viable prospects for therapeutic applications in cancer research. The present study investigates the potential application of Han: Dy3+ NCs for breast cancer treatment. The synthesized nanocomposites underwent characterization through various techniques, XPS has proven to be a valuable analytical technique for obtaining detailed information regarding various materials’ elemental composition and states. This information is of utmost importance in understanding the potential therapeutic applications of these materials. The composition of the particles was verified using SEM-EDAX analysis. The excitation spectra have revealed electronic transitions, suggesting potential cancer treatment implications. The emission spectra revealed the presence of distinct wavelengths corresponding to the emissions of Dy3+ ions. Cytotoxicity assays were conducted on the MCF7 and 4T1 breast cancer cell lines. In this study, it was observed that Han: Dy3+NCs exhibited cytotoxic effects that were dependent on the dosage administered. The concentrations at which 50% of the cells were affected were determined. The results of this study highlight the potential of Han: Dy3+ nanocomposites in the treatment of breast cancer, indicating the possibility for additional modifications and the development of targeted therapeutic approaches.

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Study of Structural and Luminescent Phase State of Hydroxyapatite Doped Nanocomposites of Dysprosium Ions for the Targeted Breast Carcinoma Cells

  • 会议论文

  • 发表日期：

    2025年

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  • K. Sai Manogna,
  • K. Kusuma,
  • G. Rajasekhara Reddy,
  • B. Deva Prasad Raju,
  • N. John Sushma

摘要

Nanomaterials are increasingly recognized as viable prospects for therapeutic applications in cancer research. The present study investigates the potential application of Han: Dy3+ NCs for breast cancer treatment. The synthesized nanocomposites underwent characterization through various techniques, XPS has proven to be a valuable analytical technique for obtaining detailed information regarding various materials’ elemental composition and states. This information is of utmost importance in understanding the potential therapeutic applications of these materials. The composition of the particles was verified using SEM-EDAX analysis. The excitation spectra have revealed electronic transitions, suggesting potential cancer treatment implications. The emission spectra revealed the presence of distinct wavelengths corresponding to the emissions of Dy3+ ions. Cytotoxicity assays were conducted on the MCF7 and 4T1 breast cancer cell lines. In this study, it was observed that Han: Dy3+NCs exhibited cytotoxic effects that were dependent on the dosage administered. The concentrations at which 50% of the cells were affected were determined. The results of this study highlight the potential of Han: Dy3+ nanocomposites in the treatment of breast cancer, indicating the possibility for additional modifications and the development of targeted therapeutic approaches.