Bioremediation of Pharmaceutically Active Compounds (PhACs): Strategies, Mechanisms, and Future Prospects
摘要
In recent years, pharmaceutically active compounds (PhACs)Pharmaceutically Active Compounds (PhACs) have emerged as ubiquitous contaminants in various environmental matrices, posing potential risks to the ecosystem. As reported in different studies, the indirect ingestion of these compounds can cause adverse effects on human health. Traditional water treatment techniques are not fully efficient to remove these compounds from wastewater and other contaminated environments. The bioremediation by utilization of microorganisms e.g., bacteria, fungi, and algae in various treatment processes like activated sludge processActivated sludge process (ASP), membrane bioreactors (MBRs)Membrane Bioreactors (MBRs), moving bed biofilm reactors (MBBRs)Moving Bed Biofilm Reactors (MBBRs) have drawn interest as a sustainable and efficient technique to degrade PhACsPharmaceutically Active Compounds (PhACs). The performance of these processes is influenced by different environmental factors such as pH, temperature, and co-contaminants. The highest efficiency for the removal of different PhACsPharmaceutically Active Compounds (PhACs) was achieved through microbe based remediation processes as reported in some studies. The sorption process using biochar has also shown higher efficiency for removing a number of PhACsPharmaceutically Active Compounds (PhACs) like diclofenac, ibuprofen, sulfamethoxazole etc. This chapter comprehensively explores the diverse microbial mechanisms involved in bioremediation of PhACsPharmaceutically Active Compounds (PhACs), elucidating the interplay between microbial consortia and genetically modified microorganisms, with special emphasis on their synergistic effects in enhancing degradation efficiency and substrate specificity. The prospect, potential challenges, limitations and possible solutions related to bioremediation techniques such as reactor design, microbial adaptability, and substrate toxicity are also explored. This review may be an invaluable resource for academics, practitioners, and policymakers involved in environmental remediation projects.