Chemically stable and easy-to-manufacture dyes are widely available due to the textile industry's rapid expansion. Due to their poor biodegrade ability in aquatic habitats, these dyes pose an environmental risk. Enzyme-linked bioremediation is being tested to reduce textile dyes’ environmental impact. We assessed the susceptibility of 10 dyes (Reactive Black 5, Reactive Red 22, Reactive Red 198, Acid Yellow 42, Reactive Blue 19, Direct Blue 15, Direct Red 28, Basic Green 4, Basic Violet 3, and Acid Orange 7) from various chemical classes using bioinformatics and molecular docking. We tested these dyes for degradation by laccase, azoreductase, peroxidase, nitroreductase, and hydrolase. The enzymes described here are from Pseudomonas putida, Bacillus subtilis, Aeromonas hydrophila, Lysinibacillus sphaericus, and Staphylococcus aureus. In silico docking investigation using AutoDock Vina software reveals enzyme-dye interaction mechanisms, stability, catalytic activity, and selectivity. The interactions between amino acids and selected dyes emphasize the importance of enzyme-driven bioremediation processes and the role each enzyme plays in decolorizing and degrading textile dyes.