The concept of fabricating a single part made of two or more materials (multi-materials) seems promising to enhance the performance limitation possess by single material parts. For metals, joining two or more metals is possible with conventional processes such welding and brazing. However, such an approach is limited to simple design parts having no intricate design or complex features. 3D printing or additive manufacturing is an advanced technology method that is well capable to produce great performance parts having intricate features. For metals, the fabrication of multi-material additive manufacturing (MMAM) is possible via the laser powder bed fusion (LPBF) method. However, such an idea is challenging due to thermal profiles’ differences of metals which may affect the printability and the interface bonding strength. In addition, the possible formation of residual stress during printing process may deteriorate the mechanical properties of MMAM parts. Such stress is normally removed via heat treatment. Performance of LPBF-ed MMAM parts may be enhanced by the crucial selection of materials, printing strategies and processing parameters. In this brief review, the concept, past successful attempts and challenges of MMAM are presented.