Craniofacial bone defects occur due to various reasons such as congenital developmental disorders (craniosynostosis, cleft lip-palate etc.), traumas and oncologic resections. The main goals of craniofacial reconstruction are to provide the patient with a proper craniofacial form, to regain function if there is loss of it, to eliminate aesthetic concerns, and to ensure the continuity of craniofacial development in a normal way for the pediatric patients. Because there is an underlying bone defect, the use of bone grafts is often indispensable in craniofacial reconstruction. As the gold standard, autologous bone grafting is the first choice under ideal conditions. However, due to limited autologous graft sources, additional surgical intervention requirements, and resulting donor site morbidities; craniofacial reconstruction has necessitated alternative solutions that combine tissue engineering and regenerative medicine. Growth factors such as bone morphogenic protein (BMP), which effect bone and cartilage formation and regulate bone healing physiology, have attracted attention in recent years. As a result of recent advances in tissue engineering and regenerative medicine; cells, tissue scaffolds, and growth factors are used together due to the importance of 3D tissue healing in craniofacial defects, and the complex nature of the tissue repair mechanism.