In this study, the prospect of encapsulating of Moringa Oleifera (MO) extract onto the composite polymeric ultrafine particles using salting-out method was investigated. MO leaves were extracted using Soxhlet extraction to obtain the bioactive compounds present. Phytochemical evaluations of the extract revealed significant levels of total phenolic content (TPC), total flavonoid content (TFC), and antioxidant activities, with values of 386.70 ± 9.25 mg GAE/g, 82.34 ± 2.57 mg QE/g, and 32.8 ± 1.91% for 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and 49.4 ± 1.64% for 2,2-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid (ABTS) radical scavenging, respectively, indicating its notable antioxidant capacity. MO extract was then encapsulated into composite ultrafine particles (nanoparticles) (NPs) containing poly-ε-caprolactone (PCL) and montmorillonite (MMT), which are now known as PCL-loaded MO/MMT NPs using salting-out method. A 24 full-factorial design with four different factors, (i) stirring speed, (ii) concentration of MMT, (iii) concentration of MO, and (iv) aqueous phase-to-organic phase ratio (Vaq/Vor), was simulated to response of encapsulation efficiency (EE%) prior to attain the optimized conditions for the formation of composite particles via salting-out method. The optimized conditions were achieved at the stringing speed of 1300 rpm, amount of MMT at 2 w/w%, MO amount of 3 w/w %, and Vaq/Vor of 1:15, resulting in EE% of 80.03%. The PCL-loaded MO/MMT nanoparticles were characterized using Scanning Electron Microscopy (SEM) and Fourier Transform Infrared Spectroscopy (FTIR). These analyses confirmed the formation of spherical nanoparticles with smooth surfaces, uniform size distributions, and the presence of characteristic functional groups.