The flourishing of crops and their subsequent productivity are significantly impaired by the strain of climatic stress. Various abiotic stresses, including drought, extreme temperatures, freezing conditions, and increased salinity, have made cultivated plants susceptible to the ongoing global climate change. The precarious survival of the plants and agricultural output is significantly reduced due to these stresses. Reactive oxygen species (ROS) are produced and accumulate in plants as a result of abiotic stressors, which damages essential biomolecules such as proteins, lipids, and nucleic acids that are found within the cells. Plant growth-promoting bacteria (PGPB) are resilient microbes that boost plant growth and crop productivity, strengthening food security under abiotic stress. They enhance plant growth through mechanisms including the synthesis of ACC deaminase, exopolysaccharides, HCN, phytohormones, extracellular polymers, siderophores, abscisic acid, and release ofvolatile organic compounds (VOCs). PGPB also enhance the antioxidant pathways in plants, supporting the prevention of oxidative stress, regulation of ion homeostasis, and maintenance of osmotic balance. They also trigger stress response genes, reprogram metabolism, and supply transcription factors. This review explores how domesticated PGPB strains can aid sustainable agriculture by mitigating abiotic stress, while also examining the potential of multi-omics to uncover new strains and mechanisms.