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Surgical resection remains the mainstay of treatment for glioma patients with the extent of resection (EOR) significantly influencing the prognosis. To achieve precise classification, prognosis prediction, and guidance of postoperative treatment, the 2016 World Health Organization classification of CNS tumors (2016 CNS WHO) incorporated molecular markers into diagnostic system. Previous studies have found that the survival benefit from surgical resection differed between different molecular subtypes of glioma patients. With the development of testing technology, intraoperative rapid molecular detection is advancing towards maturity, enabling surgical resection under molecular pathology guidance. This chapter will summarize the recent progress in glioma surgical resection guided by molecular pathology and the development of intraoperative rapid molecular detection techniques and explore the potential instructive value of molecular pathology in guidance of glioma resection.

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Surgical Strategies in the Era of Molecular Pathology

  • 章节

  • 发表日期：

    2025年

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  • Shuai Wu,
  • Chen Luo,
  • Hong Chen,
  • Zhang Xiong

摘要

Surgical resection remains the mainstay of treatment for glioma patients with the extent of resection (EOR) significantly influencing the prognosis. To achieve precise classification, prognosis prediction, and guidance of postoperative treatment, the 2016 World Health Organization classification of CNS tumors (2016 CNS WHO) incorporated molecular markers into diagnostic system. Previous studies have found that the survival benefit from surgical resection differed between different molecular subtypes of glioma patients. With the development of testing technology, intraoperative rapid molecular detection is advancing towards maturity, enabling surgical resection under molecular pathology guidance. This chapter will summarize the recent progress in glioma surgical resection guided by molecular pathology and the development of intraoperative rapid molecular detection techniques and explore the potential instructive value of molecular pathology in guidance of glioma resection.