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Radiation therapy (RT) represents an important approach for malignant tumors, mainly classified into external radiation therapy (EBRT) and internal radioisotope therapy (RIT). RT not only destroys malignant cells but also synchronously affects immunocytes in the tumor microenvironment, resulting in remodeling of the immune microenvironment, which has received much attention in recent years. Conventional RT has poor targeting ability on immunocytes and is easily tolerated by malignant cells. The rapid development of nanobiomaterials in recent years, which serve not only as carriers for delivering radiotherapeutic sensitizing agents, some of which also possess RT properties per se for the purpose of radio-immunotherapy, constitutes an important area of research in RT in the future.

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Advanced Nanobiomaterial-Mediated Radio-Immunotherapy in Malignant Cancer

  • 章节

  • 发表日期：

    2025年

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  • Ning Han,
  • Jun Hu,
  • Liu-Gen Li,
  • Cunqing Kong,
  • Fan Leng,
  • Zhi-Jie Xu,
  • Yuan-Liang Yan,
  • Tong-Fei Li

摘要

Radiation therapy (RT) represents an important approach for malignant tumors, mainly classified into external radiation therapy (EBRT) and internal radioisotope therapy (RIT). RT not only destroys malignant cells but also synchronously affects immunocytes in the tumor microenvironment, resulting in remodeling of the immune microenvironment, which has received much attention in recent years. Conventional RT has poor targeting ability on immunocytes and is easily tolerated by malignant cells. The rapid development of nanobiomaterials in recent years, which serve not only as carriers for delivering radiotherapeutic sensitizing agents, some of which also possess RT properties per se for the purpose of radio-immunotherapy, constitutes an important area of research in RT in the future.