Road profile makes running performance of the vehicle worse. As a result, the vehicle are exposed to uncomfortable vibrations, especially from the vertical direction. These vibrations cause significant damage to the pavement surface and accelerate the progression of surface deterioration. The damaged pavements further deteriorate not only the running performance of the vehicle but also the pavement itself. The progress of damage due to the interaction between vehicle vibration and rough road surface finally leads to disruption of the pavement., Various research studies on this issue of the interaction have been reported so far. As to the relation between the pavement surface and the dynamic load of the running vehicle, current research activities used by the conventional vehicle simulation software packages are established, however, there are little reports regarding the effects of local road irregularities such as manhole and fault which cause transient vibration of the vehicle taking into account life cycle cost (LCC) of pavement. In this study, the vertical acceleration of the vehicle running on the irregularities and resulting dynamic load of the pavement was obtained experimentally and calculated theoretically by use of the simple Quarter Car model. Asphalt layer damage in order to validate this study was measured by FWD (Falling Weight Deflectometer) tests.