Aiming at the scenario of cooperation between manned and unmanned operations, especially for “loyal wingman”, this paper proposes a modeling and analysis framework for heterogeneous aerial combat network considering human-in-loop, which addresses the challenges of human modeling in combat networks. Through standardized definitions of humans in decider entities, man-machine information transmission is classified formally. Then, the evaluation of operational capability for entities, operational chains and combat networks are defined. Finally, a case study of different operational chains is derived. Different simulation results imply that humans are critical in combat networks, which also demonstrates the applicability and effectiveness of the framework proposed in this paper.