The air-defense missile-artillery coordinated combat system is an integrated and coordinated system with outstanding performance in close-range air-defense operations, in which the main performance indicators of the sub-systems determine the overall indicators of the effectiveness of the weapon system. Based on the typical combat scenarios, according to the hierarchical analysis method, we analyze and calculate the combat performance of the weapon system scheme from the detection and tracking subsystem, the target destruction subsystem and the mobility protection subsystem, establish the index model with the maximum combat performance and the minimum system quality, and optimize the weapon system scheme by using the multi-objective genetic algorithm, and validate the validity of the model and the method through simulation, so as to provide a method of optimal design and evaluation for the development of the combined weapon and equipment.