This chapter explores the intersection between sustainability and the digital supply chain, elucidating the evolving landscape where environmental responsibility meets technological advancements. It delves into the practical applications, challenges, and best practices for integrating sustainability principles within digital supply chain frameworks. Through the lens of sustainable development, the chapter navigates the complexities of leveraging digital technologies to enhance supply chain sustainability, focusing on incorporating eco-friendly practices, circular economy models, and ethical sourcing. It addresses key themes such as green logistics, carbon footprint reduction, waste minimization, and utilizing data-driven insights to optimize supply chain operations while minimizing environmental impact. Additionally, the chapter discusses the role of stakeholders, emerging technologies, and regulatory frameworks in shaping sustainable practices within the digital supply chain landscape.