Sustainability and artificial intelligence (AI) represent two intriguing areas of investigation. This chapter discusses the intersection between sustainability and AI and their implications. The literature related to sustainability and AI was reviewed, and a summary of the main issues of AI and sustainability was highlighted. The chapter found that AI explains positive sustainable outcomes for stakeholders and society and can be used to leverage effects on organizations and industries to help build transformative innovations that are sustainable for human flourishing and international cohesion. From an ethical perspective, it is important to not only identify the possible implications, but also the potential dilemmas that such technologies bring. The chapter concludes that there are concerns and issues associated with AI that need to be addressed by policymakers, practitioners, and scientists. Implications and directions for future research are highlighted.