The key features of the microneedle array include painless delivery through human skin without causing any tissue damage. For microneedle skin penetration, a reliable, effective and flexible test method is needed in lieu of invitro/invivo investigations. This study includes a finite element analysis of the insertion of a solid PVA pyramidal microneedle for drug administration into human skin. The proposed microneedle has a length of 575 µm, base width of 200 µm and needle-to-needle spacing of 500 µm. The mechanical stability and skin insertion analysis are analyzed using COMSOL Multiphysics 5.6 software. The endurance of the microneedle is examined by applying a buckling load to the microneedle base which results in less stress and bending. The three layer skin model is used to conduct the microneedle penetration depth study. The simulation findings confirm that the PVA microneedle array penetrated the skin model successfully and remains unbroken.

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Insights into the Mechanical Stability Analysis of Solid PVA Pyramidal Microneedle Array for Transdermal Drug Delivery

  • A. Gowthami,
  • B. S. Sreeja

摘要

The key features of the microneedle array include painless delivery through human skin without causing any tissue damage. For microneedle skin penetration, a reliable, effective and flexible test method is needed in lieu of invitro/invivo investigations. This study includes a finite element analysis of the insertion of a solid PVA pyramidal microneedle for drug administration into human skin. The proposed microneedle has a length of 575 µm, base width of 200 µm and needle-to-needle spacing of 500 µm. The mechanical stability and skin insertion analysis are analyzed using COMSOL Multiphysics 5.6 software. The endurance of the microneedle is examined by applying a buckling load to the microneedle base which results in less stress and bending. The three layer skin model is used to conduct the microneedle penetration depth study. The simulation findings confirm that the PVA microneedle array penetrated the skin model successfully and remains unbroken.