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In this study, we develop a comprehensive numerical simulation framework to predict the Traveling Surface Acoustic Waves (TSAWs) behavior for efficient cell lysis in healthcare applications. We performed this by integrating wave propagation phenomena, material properties, and geometric configurations. TSAWs were generated and propagated to cells within a microfluidic channel, using interdigitated transducers (IDT) on a piezoelectric substrate. Numerical simulations and experimental validation demonstrate high lysis efficiency (>95%) within seconds. This approach shows promise for diagnostic toolkits, protein purification kits, and pathogen detection.

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Advanced Design and 3D Numerical Simulation of Traveling Surface Acoustic Waves for Healthcare Applications

  • 会议论文

  • 发表日期：

    2025年

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  • Sushama Agarwalla,
  • Sunil Kumar Singh,
  • Suhanya Duraiswamy

摘要

In this study, we develop a comprehensive numerical simulation framework to predict the Traveling Surface Acoustic Waves (TSAWs) behavior for efficient cell lysis in healthcare applications. We performed this by integrating wave propagation phenomena, material properties, and geometric configurations. TSAWs were generated and propagated to cells within a microfluidic channel, using interdigitated transducers (IDT) on a piezoelectric substrate. Numerical simulations and experimental validation demonstrate high lysis efficiency (>95%) within seconds. This approach shows promise for diagnostic toolkits, protein purification kits, and pathogen detection.