This paper presents a model for predicting visual comfort of natural lighting office, considering both the horizontal paper work and vertical VDT (Visual Display Terminal) work mode, based on field experiments and questionnaires. By using the prediction model, an intelligent prediction platform system for visual comfort is built. The model and platform are applied to investigate the prototype office space model in Harbin, China. By simulation and control variable method, the influence of various building facade form on the visual comfort of natural lighting office space is analyzed. Finally, this paper summarizes and proposes office building facade design strategies based on visual comfort, to enhance the overall visual comfort level of office space, and guide office building design.