The challenges of climate change represent a major problem for food safety around the world. Long-term changes in patterns of temperature, precipitation, humidity, and extreme weather events are affecting agricultural activities, crop production, and the nutritional quality of most food crops. The allergy of germs, microorganisms, and pests to environmental factors has revealed that climate change is leading to the emergence of invasive stranger species that harm the health of plants and animals. Warming of surface seawater and increased input of nutrients lead to an abundance of toxin-producing algae causing rampant seafood contamination. Global efforts are continuing to reduce the emissions of greenhouse gases and mitigate the effect of climate change on feed safety related to plant, animal, human, and environmental health. This chapter discusses the impact of climate change on food safety and the efforts made internationally to decrease the microorganisms, chemicals, and biological contaminants that affect the health of plants, animals, and humans.