Aiming at the problems of high flow resistance, large mass, and weak pressure resistance in the traditional skin structure, this paper constructs a new type of pressure-resistant-drag reduction skin based on the bionic microgroove drag reduction technology and the theory of mechanical metamaterials. It analyzes and calculates its pressure resistance and drag reduction ability based on the finite element method. The results show that the flexible skin supported by the negative Poisson's ratio structure has a drag reduction rate of 2.75% higher than that supported by the traditional frame structure. On this basis, the drag reduction rate is used as an index to analyze the drag reduction performance of the skin under different honeycomb concave angle parameters and different sailing speeds. The results show that the flexible skin shows the highest drag reduction rate at 70°, while the drag reduction effect at other angles is greatly weakened, and even the resistance is increased. When the honeycomb concave angle is 70°, the drag reduction rate increases with the speed increase. At the same time, in terms of pressure resistance, the performance of the new skin is also significantly better than that of the traditional flexible skin. The mass is only 19.8% of the solid flexible skin structure and can withstand hydrostatic pressure of more than 10,000 m water depth.