The flexible structures and components of large spacecraft are easily affected by vibration and instability, which can cause serious engineering accidents. Distributed vibration control is the best choice as an efficient and reliable vibration method. The basic idea of substructure method is consistent with distributed control. In this paper, the distributed vibration control problem of large flexible spacecraft is studied. The theory of Craig-Bampton method is studied deeply, and distributed vibration control is combined with substructure method, which is introduced into the active vibration suppression problem of large space truss structures. Based on the topological communication relationship between the subcontrol system and subsystems, the feedback gain of the subcontroller and the interaction between the subsystems are combined to form a complete feedback regulation of the distributed vibration control system, and the distributed vibration control system is established. Numerical examples demonstrate the effectiveness of the proposed method and the robustness of distributed vibration control, which has great application potential in practical engineering.