Halophytes represent a remarkable group of plants capable of thriving in saline soils, having a crucial role in reducing soil erosion and offering diverse benefits such as fodder, energy production, medicinal applications, and phytoremediation. Among the halophytes, Sesuvium portulacastrum stands out as a key species garnering great interest due to the multifaceted applications. As the landscape of research evolves, groundbreaking genomic and biotechnological advancements are now paving the way for innovative techniques to enhance the potential of S. portulacastrum for a wide range of applications. This plant has showcased its incredible abilities in phytoremediation, medicinal uses, food production, and industrial applications, primarily owing to its resilience against various abiotic stresses. Given this backdrop, integrating modern biotechnology with Sesuvium research is more critical than ever. This chapter delves into the exciting intersection of contemporary technologies, including transgenic plants, genome editing, metabolic engineering, molecular markers, secondary metabolite production, as well as nano- and synthetic biology. An in-depth exploration of these innovative approaches will illuminate the future prospects for S. portulacastrum, outlining the challenges and potential advancements that lie ahead in plant biology and sustainable agriculture.